Title of article
Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents
Author/Authors
Varaprasad، نويسنده , , Chamakura V.N.S. and Ramasamy، نويسنده , , Kanda S. and Girardet، نويسنده , , Jean-Luc and Gunic، نويسنده , , Esmir and Lai، نويسنده , , Vicky and Zhong، نويسنده , , Weidong and An، نويسنده , , Haoyun and Hong، نويسنده , , Zhi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
10
From page
25
To page
34
Abstract
Several Toyocamycin (4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio (18) and 5-carboxamide oxime derivatives (23 and 27) of Toyocamycin were found to have good activity and selectivity.
Keywords
HCV NS5B inhibitors , Toyocamycin , 3-d]pyrimidine nucleosides
Journal title
Bioorganic Chemistry: an International Journal
Serial Year
2007
Journal title
Bioorganic Chemistry: an International Journal
Record number
1385891
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