Title of article
Application of the bridgehead fragments for the design of conformationally restricted melatonin analogues
Author/Authors
Zefirova، نويسنده , , Olga N. and Baranova، نويسنده , , Tatiana Yu and Ivanova، نويسنده , , Anna A. and Ivanov، نويسنده , , Andrei A. and Zefirov، نويسنده , , Nikolay S.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
6
From page
67
To page
72
Abstract
Conformationally constrained analogues of the hormone melatonin with a side chain incorporated into the bicyclic bridgehead core were synthesized based on the homology modeling and molecular docking studies performed for the MT2 melatonin receptor. The methoxy-indole derivative fused with exo-N-acetamino-substituted bicyclo[2.2.2]octane was found to possess nanomolar MT2 receptor affinity.
Keywords
Bridgehead fragments , Melatonin receptors , Conformational restriction
Journal title
Bioorganic Chemistry: an International Journal
Serial Year
2011
Journal title
Bioorganic Chemistry: an International Journal
Record number
1386114
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