Title of article :
Mechanism for sulfur acquisition by the alkanesulfonate monooxygenase system
Author/Authors :
Ellis، نويسنده , , Holly R.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Abstract :
The bacterial alkanesulfonate monooxygenase system is involved in the acquisition of sulfur from organosulfonated compounds during limiting sulfur conditions. The reaction relies on an FMN reductase to supply reduced flavin to the monooxygenase enzyme. The reaction catalyzed by the alkanesulfonate monooxygenase enzyme involves the carbon–sulfur bond cleavage of a wide range of organosulfonated compounds. A C4a-(hydro)peroxyflavin is the oxygenating intermediate in the mechanism of desulfonation by the alkanesulfonate monooxygenase. This review discusses the physiological importance of this system, and the individual kinetic parameters and mechanistic properties of this enzyme system.
Keywords :
Alkanesulfonate monooxygenase , FMN reductase , SsuE , SsuD , Sulfur limitation , Two-component monooxygenase system
Journal title :
Bioorganic Chemistry: an International Journal
Journal title :
Bioorganic Chemistry: an International Journal