Author/Authors :
K. and Bonkobara، نويسنده , , Makoto and Saito، نويسنده , , Taro and Yamashita، نويسنده , , Masahiro and Tamura، نويسنده , , Kyoichi and Yagihara، نويسنده , , Hiroko and Isotani، نويسنده , , Mayu and Sato، نويسنده , , Takashi and Washizu، نويسنده , , Tsukimi، نويسنده ,
Abstract :
A case of canine non-T, non-B lymphoid leukaemia was determined to be of natural killer (NK) cell lineage by detecting specific expression of canine CD56 mRNA by reverse transcriptase polymerase chain reaction analysis. Although NK cells are usually considered to be morphologically large granular lymphocytes, the malignant NK cells in this case were agranular and blast-like, resembling human blastic NK cell leukaemia. The prognosis of human NK cell leukaemia is usually poor. In this case, the dog died 10 days after initial presentation, despite chemotherapy.
Keywords :
natural killer cells , CD56 , Lymphoid leukaemia , canine
