Title of article :
Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: A randomised, double blind, placebo-controlled study
Author/Authors :
Willemse، نويسنده , , T. and Bardagi، نويسنده , , M. and Carlotti، نويسنده , , D.N. and Ferrer، نويسنده , , L. and Fondati، نويسنده , , A. La Fontaine، نويسنده , , J. and Leistra، نويسنده , , M. and Noli، نويسنده , , C. and Ordeix، نويسنده , , L. and Scarampella، نويسنده , , F. and Schleifer، نويسنده , , S. and Sinke، نويسنده , , J. and Roosje، نويسنده , , P.، نويسنده ,
Abstract :
A randomised, placebo-controlled, double blind study was conducted on 25 dogs that had atopic dermatitis, together with skin test reactivity and elevated serum IgE to Dermatophagoides farinae (Df) and at least one additional allergen. Dogs were treated with either a Df-restricted immunotherapy solution (n = 14) or a placebo (n = 11) and evaluated 6 weeks and 3, 5, 7 and 9 months after the initiation of treatment using a clinical scoring system (SASSAD) and pruritus analogue scale scores. The Df-restricted solution and the placebo had an equal effect on both pruritus and the skin manifestations (P > 0.05). The results of this study indicate that in dogs with atopic dermatitis based on hypersensitivity to environmental allergens in addition to D. farinae, Df-restricted immunotherapy is insufficient to control the disease. Consequently, a solution for allergen-specific immunotherapy should remain customised.
Keywords :
atopic dermatitis , Dermatophagoides farinae , canine , Allergen-specific immunotherapy
