Title of article :
A novel day blindness in sheep: Epidemiological, behavioural, electrophysiological and histopathological studies
Author/Authors :
Shamir، نويسنده , , Merav H. and Ofri، نويسنده , , Ron and Bor، نويسنده , , Amir and Brenner، نويسنده , , Ori and Reicher، نويسنده , , Shay and Obolensky، نويسنده , , Alexey and Averbukh، نويسنده , , Edward and Banin، نويسنده , , Eyal and Gootwine، نويسنده , , Elisha، نويسنده ,
Abstract :
Four genetically related Improved Awassi sheep flocks had sporadic births of lambs with congenital visual impairments that differed from other known forms of sheep blindness. Pedigree analysis suggested an autosomal recessive mode of inheritance. Behavioural studies of 4-month old affected lambs showed that their day vision (but not night vision) was impaired. Electrophysiological results at this age demonstrated diminished function of cones but not rods. Histopathological and immunohistochemical evaluation of affected retinas from 5-month old lambs revealed both red-green and blue cones, suggesting that the behavioural day blindness and reduced cone electroretinograms reflect cone dysfunction rather than severe cone photoreceptor loss. Awassi day blindness may be a form of achromatopsia.
