Title of article
Serotonin transporter activity in platelets and canine aggression
Author/Authors
Rosado، نويسنده , , Belén and Garcيa-Belenguer، نويسنده , , Sylvia and Palacio، نويسنده , , Jorge and Chacَn، نويسنده , , Gema and Villegas، نويسنده , , Ainara and Alcalde، نويسنده , , Ana I.، نويسنده ,
Issue Information
فصلنامه با شماره پیاپی سال 2010
Pages
2
From page
104
To page
105
Abstract
Several studies have suggested an inhibitory action of the serotonergic system in the regulation of canine aggression, but the role of the serotonin (5-HT) transporter (5-HTT) has not been investigated. Platelet 5-HT uptake has been proposed as a peripheral marker of brain 5-HTT. The aim of the study was to investigate the relationship between platelet 5-HTT activity and canine aggression by measuring the rate of 5-HT uptake mediated by 5-HTT in platelets and serum concentrations of 5-HT in both aggressive (n = 14) and non-aggressive dogs (n = 17). Aggressive dogs showed significantly higher 5-HT uptake by 5-HTT in platelets and lower serum concentrations of 5-HT, compared with the control group. These results suggested an association between an alteration in the serotonergic system and canine aggression, possibly mediated by an increased 5-HT transport.
Keywords
Serotonin , Transporter , Aggression , platelet , canine
Journal title
The Veterinary Journal
Serial Year
2010
Journal title
The Veterinary Journal
Record number
1394459
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