Title of article :
LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs
Author/Authors :
Lequarré، نويسنده , , Anne-Sophie and Andersson، نويسنده , , Leif and André، نويسنده , , Catherine and Fredholm، نويسنده , , Merete and Hitte، نويسنده , , Christophe and Leeb، نويسنده , , Tosso and Lohi، نويسنده , , Hannes and Lindblad-Toh، نويسنده , , Kerstin and Georges، نويسنده , , Michel، نويسنده ,
Issue Information :
فصلنامه با شماره پیاپی سال 2011
Pages :
5
From page :
155
To page :
159
Abstract :
The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.
Keywords :
canine , Inherited disorders , LUPA , genetics , Single nucleotide polymorphism arrays
Journal title :
The Veterinary Journal
Serial Year :
2011
Journal title :
The Veterinary Journal
Record number :
1395214
Link To Document :
بازگشت