Titania-based bioactive materials

Bioactive materials hitherto clinically used are based on silicate or phosphate. Recently, various kinds of bioactive materials with different mechanical properties are being developed on the basis of titania. A bioactive material with high fracture toughness was obtained by surface modification of titanium metal with an amorphous sodium titanate. An osteoinductive material with high mechanical strength was obtained by surface modification of porous titanium metal with anatase. A bioactive material with high flexibility was obtained by surface modification of polyethylene terephthalate fiber fabric with brookite. A bioactive material with analogous mechanical properties to those of human cortical bone was obtained by dispersing nano-sized anatase particles in a polyethylene. A bioactive material with self-setting property was obtained by mixing anatase particles with polymethyl methacrylate (PMMA) particles of a conventional PMMA cement.