Author/Authors :
Gholipour Baradari، Afshin نويسنده Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran , , Hiva and Damia، نويسنده , , Chantal and Dutreih-Colas، نويسنده , , Maggy and Laborde، نويسنده , , Etienne and Pécout، نويسنده , , Nathalie and Champion، نويسنده , , Eric and Chulia، نويسنده , , Dominique and Viana، نويسنده , , Marylène، نويسنده ,
Abstract :
Drug loaded porous calcium phosphate bone substitutes are studied for targeted drug delivery applications. In this study, porous hydroxyapatite and beta-tricalcium phosphate pellets were investigated as anti-inflammatory drug carriers and their ibuprofen adsorption and release properties were compared. While the adsorption equilibrium time of 1 h was obtained for both pellets, hydroxyapatite pellets showed a higher adsorption capacity than beta-tricalcium phosphate. The physico-chemical characterisations of loaded pellets confirmed an ibuprofen reversible physisorption on both hydroxyapatite and beta-tricalcium phosphate pellets. Moreover, higher adsorption capacity of hydroxyapatite was attributed to their physical differences. The in vitro ibuprofen release evaluation showed 100% release of ibuprofen from both hydroxyapatite and beta-tricalcium phosphate pellets which was found to be compatible with the obtained interactions between the pellets and ibuprofen.
Keywords :
IBUPROFEN , Hydroxyapatite , Beta tricalcium phosphate , Porous pellets , Drug delivery system
