Author/Authors :
Mansouri Torshizi، Mahnaz نويسنده Novin Infertility Treatment Center, Mashhad, Iran , , Khalighi، Amir Reza نويسنده Mashhad University of Medical Sciences, Mashhad, Iran. , , Fadavi Islam، Mahla نويسنده Novin Infertility Treatment Center, Mashhad, Iran , , Aram، Rahele نويسنده Novin Infertility Treatment Center, Mashhad, Iran , , Sabouri، Elham نويسنده Novin Infertility Treatment Center, Mashhad, Iran , , Khalilifar، Hekmat نويسنده Novin Infertility Treatment Center, Mashhad, Iran , , Roustaee، Hesam نويسنده Novin Infertility Treatment Center, Mashhad, Iran ,
Abstract :
Background: Human T-cell Lymphotrophic virus type 1 (HTLV-1) has infected more than 20 million people worldwide. Northeast of Iran, Mashhad, the capital of Razavi Khorasan Province, is endemic for HTLV-1 with a prevalence of 3% among general population. Objective: We evaluated the ICSI outcome in our program for (HTLV-1) serodiscordant couples (SDCs) with the female infected in comparison with control group. Materials and Methods: This study was performed between 2007 and 2011 in Novin Infertility Treatment Center (Mashhad, Iran). We examined 32 ICSI cycles of HTLV-1 infected women in comparison with an age matched control group (n=62). ICSI outcome was compared regarding fertilization rate (FR), embryo quality parameters, implantation rate (IR), clinical pregnancy rate (PR), and abortion rate (AR). Results: Fertilization (p=0.15), implantation (p=0.33), and pregnancy rate (p=0.12) were similar between the groups. No difference was found regarding the number of transferred embryos (on day 2 or 3) and cryopreserved embryos, multiple pregnancies, or abortion rates between the groups. Conclusion: Our results suggest that the embryo quality and ICSI outcome are not affected by HTLV-1 infection in serodiscordant couples. The major finding of this study is that the outcome of ICSI in HIV-I-infected patients and seronegative controls is similar.
