Polydimethylsiloxanes in supercritical solvent impregnation (SSI) of polymers

Polydimethylsiloxanes (PDMS) are surfactants largely used at supercritical conditions for different applications. In this work PDMS with relatively low molecular weight have been used; their solubility in supercritical carbon dioxide at different conditions has been determined. They can be successfully used for increasing the solubility of some drugs in supercritical carbon dioxide. The use of PDMS for the production of controlled drug release products has been evaluated.