Rich information format surface plasmon resonance biosensor based on array of diffraction gratings

We report a new optical biosensor platform for high throughput label-free monitoring of biomolecular interactions. This biosensor platform is based on spectroscopy of surface plasmons on an array of miniature diffraction gratings. Each miniature grating serves as an independent sensing element and allows the monitoring of refractive index changes induced by biomolecular interactions on the grating surface. The presented sensor concept shows potential for real-time observation of thousands of interactions on a single sensor chip. In this paper, we demonstrate a prototype device consisting of an SPR sensor chip with 216 sensing channels, a fluidic system for sample distribution on the sensor chip and an optical chip readout system.