Title of article :
Experimental investigation and modeling of the solubility of carvedilol in supercritical carbon dioxide
Author/Authors :
Shojaee، نويسنده , , Safar Ali and Rajaei، نويسنده , , Hamid and Hezave، نويسنده , , Ali Zeinolabedini and Lashkarbolooki، نويسنده , , Mostafa and Esmaeilzadeh، نويسنده , , Feridun، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
6
From page :
42
To page :
47
Abstract :
This study was aimed to measure the solubility of carvedilol in the temperature and pressure ranges of 308⿿338 K and 160 bar to 400 bar, respectively. In this direction, a homemade high pressure visual equilibrium cell was used to measure the solubility of carvedilol using a static method coupled with gravimetric technique. The results revealed that the carvedilol solubility was ranged between 1.12 ÿ 10⿿5 and 5.01 ÿ 10⿿3 based on the mole fraction (mole of carvedilol/mole of carvedilol + mole of CO2) in this study as the temperature and pressure was changed. Finally, the results were correlated using four density-based semi-empirical correlations including Chrastil, Mendez⿿Santiago⿿Teja (MST), Bartle et al., and Kumar and Johnston (K-J) models. Results revealed that although the K-J model leads to the lowest average absolute relative deviation percent (AARD %) of 6.27%, but it could not be considered as the most accurate correlation since all the used four correlations introduces AARD % of about 6⿿10% which may be in the same range as the experimental error.
Keywords :
Carvedilol , Supercritical carbon dioxide , solubility , Correlation
Journal title :
Journal of Supercritical Fluids
Serial Year :
2013
Journal title :
Journal of Supercritical Fluids
Record number :
1427400
Link To Document :
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