Title of article :
Computational tools for metabolic engineering
Author/Authors :
Copeland، نويسنده , , Wilbert B. and Bartley، نويسنده , , Bryan A. and Chandran، نويسنده , , Deepak and Galdzicki، نويسنده , , Michal and Kim، نويسنده , , Kyung H. and Sleight، نويسنده , , Sean C. and Maranas، نويسنده , , Costas D. and Sauro، نويسنده , , Herbert M.، نويسنده ,
Issue Information :
دوماهنامه با شماره پیاپی سال 2012
Abstract :
A great variety of software applications are now employed in the metabolic engineering field. These applications have been created to support a wide range of experimental and analysis techniques. Computational tools are utilized throughout the metabolic engineering workflow to extract and interpret relevant information from large data sets, to present complex models in a more manageable form, and to propose efficient network design strategies. In this review, we present a number of tools that can assist in modifying and understanding cellular metabolic networks. The review covers seven areas of relevance to metabolic engineers. These include metabolic reconstruction efforts, network visualization, nucleic acid and protein engineering, metabolic flux analysis, pathway prospecting, post-structural network analysis and culture optimization. The list of available tools is extensive and we can only highlight a small, representative portion of the tools from each area.
Keywords :
Metabolic engineering , Software , Genome-scale metabolic networks , network visualization
Journal title :
Metabolic Engineering
Journal title :
Metabolic Engineering