Author/Authors :
Alessandro Serretti، نويسنده , , A and Macciardi، نويسنده , , F and Cusin، نويسنده , , C and Lattuada، نويسنده , , Daniel Souery، نويسنده , , D and Lipp، نويسنده , , O and Mahieu، نويسنده , , B and Van Broeckhoven، نويسنده , , C and Blackwood، نويسنده , , D and Muir، نويسنده , , W and Aschauer، نويسنده , , H.N and Heiden، نويسنده , , A.M and Ackenheil، نويسنده , , M and Fuchshuber، نويسنده , , S and Raeymaekers، نويسنده , , P and Verheyen، نويسنده , , G and Kaneva، نويسنده , , R and Jablensky، نويسنده , , A and Papadimitriou، نويسنده , , G.N and Dikeos، نويسنده , , D.G and Stefanis، نويسنده , , C.N and Smeraldi، نويسنده , , Julien Mendlewicz، نويسنده , , J، نويسنده ,
Abstract :
Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients.
Keywords :
Dopamine receptors , DRD3 , linkage , bipolar disorder , Tyrosine hydroxylase , DRD2
