Author/Authors :
Gildengers، نويسنده , , Ariel G. and Houck، نويسنده , , Patricia R. and Mulsant، نويسنده , , Benoit H. and Pollock، نويسنده , , Bruce G. and Mazumdar، نويسنده , , Sati and Miller، نويسنده , , Mark D. and Dew، نويسنده , , Mary Amanda and Frank، نويسنده , , Ellen and Kupfer، نويسنده , , David J. and Reynolds III، نويسنده , , Charles F.، نويسنده ,
Abstract :
Objective: The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate. Methods: Three studies of elderly depressed patients provided data on antidepressant treatment response in 323 subjects, treated in protocols using either nortriptyline or paroxetine. We grouped the subjects by current age: ‘young-old’ (59–69, N=163), ‘middle-old’ (70–75, N=80), and ‘older-old’ (76–99, N=80). We employed mixed-effect random regression analyses to examine Hamilton Rating Scale for Depression scores over 12 weeks of acute treatment. Results: Older-old patients responded as quickly and successfully as the young- and middle-old. Conclusions: Major depression in the very old can be treated as successfully as in early old age.
