Title of article :
Motor activity and autonomic cardiac functioning in major depressive disorder
Author/Authors :
Volkers، نويسنده , , Anita C and Tulen، نويسنده , , Joke H.M and van den Broek، نويسنده , , Walter W and Bruijn، نويسنده , , Jan A and Passchier، نويسنده , , Jan and Pepplinkhuizen، نويسنده , , Lolke، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
8
From page :
23
To page :
30
Abstract :
Background: The daily pattern of motor activity and the autonomic cardiovascular regulation were studied in major depression to quantify changes in psychomotor function and autonomic cardiac functioning. Additionally, relationships between motor activity parameters, cardiovascular measures and specific clinical features were examined. Methods: Wrist-actigraphy was used to monitor 24-h motor activity for 67 unmedicated (unipolar) depressed inpatients and 64 control subjects. During supine rest, spectral analysis was applied to assess HR and SBP variability, a baroreflex sensitivity (BRS) index and the respiratory frequency, in addition to mean heart rate (HR) and blood pressure (BP) levels for the patient group and a second control group (N=51). Results: The patients showed a lower motor activity level and a reduced fragmentation of motor activity during wake, and a higher motor activity level and a decreased immobility during sleep. The mean HR and DBP level and the respiratory frequency were higher in the patient group than in the control group, but no differences in HR and SBP variability or BRS were found. Furthermore, motor activity parameters and cardiovascular measures of the patients were related to agitation and retardation and overall, patients with lower motor activity levels demonstrated lower SBP levels. Conclusions: This study confirms that the 24-h pattern of motor activity is altered in unmedicated depressed inpatients, but limited evidence was found for an autonomic cardiac dysfunction. Within the patient group there were relationships between motor activity parameters, cardiovascular measures, and clinical features, but the underlying neurobiological pathways need to be further explored.
Keywords :
Motor Activity , Wrist-actigraphy , Spectral Analysis , Major depressive disorder , Autonomic cardiac functioning
Journal title :
Journal of Affective Disorders
Serial Year :
2003
Journal title :
Journal of Affective Disorders
Record number :
1430667
Link To Document :
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