Title of article :
Gabapentin in antipsychotic-induced tardive dyskinesia: results of 1-year follow-up
Author/Authors :
Hardoy، نويسنده , , Maria Carolina and Carta، نويسنده , , Mauro Giovanni and Carpiniello، نويسنده , , Bernardo and Cianchetti، نويسنده , , Carlo and Congia، نويسنده , , Socrate and D’Errico، نويسنده , , Immacolata and Emanuelli، نويسنده , , Guido and Garonna، نويسنده , , Franco and Hardoy، نويسنده , , Maria Julieta and Nardini، نويسنده , , Marcello، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
6
From page :
125
To page :
130
Abstract :
Background: In a previous study, improvement of antipsychotic-induced blefarospasm and involuntary oral-mandibulo movements were observed with the use of the anticonvulsant drug gabapentin among affectively ill patients who had been exposed to maintenance neuroleptics. The results reported in the present paper represent the sequel to the previous study. Methods: The purported efficacy of gabapentin in the treatment of tardive dyskinesia has been assessed in an open design 1-year follow-up study, in which 30 schizoaffective, bipolar I and schizophrenic patients from seven Italian centres were evaluated by means of AIMS. The results showed a statistically significant time-related decrease in AIMS scores. The mean percentage of improvement at AIMS was 47.5±18.2%. An improvement of more than 35% after 1 year in 76% of the subjects who completed the trial (n=25) and in 63.3% of the entire sample admitted to the study was revealed. Limitation: Open trial. Conclusion: The introduction of new antipsychotic drugs has probably already limited the problems related to tardive dyskinesia. However, this type of side-effect is also observed during the course of treatment with atypical neuroleptics albeit with a lesser frequency. The fact that gabapentin treatment may have further improved clinical conditions of patients in whom therapeutic protocols had already been modified, appears to suggest exertion of a possible synergic action by the new neuroleptics on tardive dyskinesia.
Keywords :
Tardive dyskinesia , Atypical antipsychotics , ANTICONVULSANTS , Movement disorders , Affective Disorders , Gabapentin
Journal title :
Journal of Affective Disorders
Serial Year :
2003
Journal title :
Journal of Affective Disorders
Record number :
1430728
Link To Document :
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