Author/Authors :
Farina، نويسنده , , Benedetto and Della Marca، نويسنده , , Giacomo and Grochocinski، نويسنده , , Victoria J. and Mazza، نويسنده , , Marianna and Buysse، نويسنده , , Daniel J. and Di Giannantonio، نويسنده , , Massimo and Francesco Mennuni، نويسنده , , Gioacchino and De Risio، نويسنده , , Sergio and Kupfer، نويسنده , , David J. and Frank، نويسنده , , Ellen، نويسنده ,
Abstract :
Background: The aim of this study was to evaluate the microstructure of the EEG sleep of depressed subjects by cyclic alternating pattern (CAP) analysis. Methods: 78 patients affected by major depression and 18 control subjects matched for age and sex underwent a full night polysomnographic study. Results: A significant increase in CAP rate (60 versus 35%) was found in the patients group compared to controls while no significant difference was found with the traditional analysis. Conclusion: In depressed subjects CAP analysis is able to show a microstructural sleep impairment, which is not evident at the macrostructural level, providing an objective measure of sleep disturbance in those patients.
Keywords :
Cyclic alternating pattern , microstructure , Arousals , EEG sleep , depression , Sleep disorders
