Phenytoin as an augmentation for SSRI failures: A small controlled study

Background m augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures. s five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings. s ect was found. tions tudy was a small study. sions mʹs ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.