Author/Authors :
Yang، نويسنده , , Cong Fuzhong and Li Yong، نويسنده , , Yihan and Xie، نويسنده , , Dong and Shao، نويسنده , , Chunhong and Ren، نويسنده , , Jianer and Wu، نويسنده , , Wenyuan and Zhang، نويسنده , , Ning and Zhang، نويسنده , , Zhen and Zou، نويسنده , , Ying and Zhang، نويسنده , , Jiulong and Qiao، نويسنده , , Dongdong and Gao، نويسنده , , Chengge and Li، نويسنده , , Youhui and Hu، نويسنده , , Jian and Deng، نويسنده , , Hong and Wang، نويسنده , , Gang and Du، نويسنده , , Bo and Wang، نويسنده , , Xumei and Liu، نويسنده , , Tiebang and Gan، نويسنده , , Zhaoyu and Peng، نويسنده , , Juyi and Wei، نويسنده , , Bo and Pan، نويسنده , , Jiyang and Chen، نويسنده , , Honghui and Sun، نويسنده , , Shufan and Jia، نويسنده , , Hong and Liu، نويسنده , , Ying and Chen، نويسنده , , Qiaoling and Wang، نويسنده , , Xueyi and Cao، نويسنده , , Juling and Lv، نويسنده , , Luxian and Chen، نويسنده , , Yunchun and Ha، نويسنده , , Baowei and Ning، نويسنده , , Yuping and Chen، نويسنده , , YiPing and Kendler، نويسنده , , Kenneth S. and Flint، نويسنده , , Jonathan J. Shi، نويسنده , , Shenxun and Kendler، نويسنده ,
Abstract :
Background
duals with early-onset depression may be a clinically distinct group with particular symptom patterns, illness course, comorbidity and family history. This question has not been previously investigated in a Han Chinese population.
s
mined the clinical features of 1970 Han Chinese women with DSM-IV major depressive disorder (MDD) between 30 and 60 years of age across China. Analysis of linear, logistic and multiple logistic regression models was used to determine the association between age at onset (AAO) with continuous, binary and discrete characteristic clinical features of MDD.
s
r AAO was associated with more suicidal ideation and attempts and higher neuroticism, but fewer sleep, appetite and weight changes. Patients with an earlier AAO were more likely to suffer a chronic course (longer illness duration, more MDD episodes and longer index episode), increased rates of MDD in their parents and a lower likelihood of marriage. They tend to have higher comorbidity with anxiety disorders (general anxiety disorder, social phobia and agoraphobia) and dysthymia.
sions
AAO in MDD may be an index of a more severe, highly comorbid and familial disorder. Our findings indicate that the features of MDD in China are similar to those reported elsewhere in the world.
