Author/Authors :
Anada، نويسنده , , Takahisa and Masuda، نويسنده , , Taisuke and Honda، نويسنده , , Yoshitomo and Fukuda، نويسنده , , Junji and Arai، نويسنده , , Fumihito and Fukuda، نويسنده , , Toshio and Suzuki، نويسنده , , Osamu، نويسنده ,
Abstract :
We have developed a novel multicellular aggregate (spheroid) culture device that utilizes thin polydimethylsiloxane membrane deformation by decompression. The device was capable of producing thousands of spheroids rapidly at a time and regulating the diameter of spheroids with narrow size distribution. The spheroids were easily retrieved from the device noninvasively. These characteristics of the device suggest that it has the potential for use in a wide variety of applications, such as drug screening and tissue engineering.
