Multiwalled carbon nanotubes embedded molecularly imprinted polymer-modified screen printed carbon electrode for the quantitative analysis of C-reactive protein

In this work, we have applied the principle of biomimiking by incorporating 2-acryl amidoethyldihydrogen phosphate monomer which acts as if phosphotidyl choline natural binder in the synthesis of a novel C-reactive protein imprinted polymer. For C-reactive protein determination, an imprinted polymer modified screen printed carbon electrode fabricated adapting ‘grafting-to’ modification was used. The modified surface was characterized by atomic force microscopy and scanning electron microscopy analyses. The limit of detection was found to be 0.04 μg mL−1 (S/N = 3) in aqueous environment. To validate the methodology and efficacy of proposed sensor, detection of C-reactive protein was also examined in human blood serum.