Author/Authors :
Lim، نويسنده , , Soo-Yeon and Yoon، نويسنده , , Doo-Ha and Ha، نويسنده , , Do Yeon and Ahn، نويسنده , , Jung mo and Kim، نويسنده , , Dae Il and Kown، نويسنده , , Hyockman and Ha، نويسنده , , Hyun-Joon and Kim، نويسنده , , Hae-Jo، نويسنده ,
Abstract :
We report a rhodamine-based fluorescent probe (1) for cysteine (Cys). Masked with a para-hydroxybenzyl alcohol (HBA) unit, the probeʹs initial weak fluorescence is converted to strong fluorescence through a series of reactions of Michael addition and intramolecular cyclization of Cys, followed by deprotection of HBA. The caged probe (1) exhibits a selective and sensitive response toward Cys over homocysteine (Hcy) and glutathione (GSH) in HEPES buffer.
Keywords :
Chemodosimeter , cyclization , Cysteine , Rhodamine , fluorescence
