Title of article
Electrochemical cleavage of DNA in the presence of copper–sulfosalicylic acid complex
Author/Authors
Wang، نويسنده , , Yan-Ling and Liu، نويسنده , , Yun-Chun and Yang، نويسنده , , Zhou-Sheng and Zhao، نويسنده , , Guang-Chao، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
77
To page
81
Abstract
Electrochemical cleavage of DNA in the presence of copper–sulfosalicylic acid [Cu(ssal)22+] complex was studied. The cleavage was observed in a certain potential region where redox cycling of Cu(ssal)22+/Cu(ssal)2+ took place. Cu(ssal)22+ complex mediate generation of reactive oxygen species from O2 by the Fenton reaction, these radicals are capable of damaging DNA. The cleaved DNA fragments were separated by high-performance liquid chromatography (HPLC). The experimental results indicated that the method for electrochemical cleavage of DNA by Cu(ssal)22+ complex was simple and efficient.
Keywords
DNA cleavage , Cu(ssal)22+ complex , HPLC , electrochemical
Journal title
Bioelectrochemistry
Serial Year
2004
Journal title
Bioelectrochemistry
Record number
1451289
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