Title of article :
Determination of mirtazapine and its demethyl metabolite in plasma by high-performance liquid chromatography with ultraviolet detection: Application to management of acute intoxication
Author/Authors :
Romiguieres، نويسنده , , T and Pehourcq، نويسنده , , F and Matoga، نويسنده , , Bernard Bégaud، نويسنده , , B and Jarry، نويسنده , , C، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Mirtazapine is a new centrally acting noradrenergic and specific serotonin antidepressant, with an active demethyl metabolite. For toxicological purposes, a specific and accurate RP-HPLC assay was developed for the simultaneous plasma determination of these compounds. A linear response was observed over the concentration range 50–500 ng/ml. A good accuracy (bias <10%) was achieved for all quality controls, with intra-day and inter-day variation coefficients less than 8.3%. The lower limit of quantification was 20 ng/ml, without interferences with endogenous or exogenous components. This rapid method (run time <12 min) was used to manage three intoxications involving mirtazapine.
Keywords :
Mirtazapine , Demethylmirtazapine
Journal title :
Journal of Chromatography B
Journal title :
Journal of Chromatography B