Author/Authors :
Hare، نويسنده , , L.G. and Mitchel، نويسنده , , D.S. and Millership، نويسنده , , J.S. and Collier، نويسنده , , P.S. and McElnay، نويسنده , , J.C. and Shields، نويسنده , , M.D. and Carson، نويسنده , , D.J. and Fair، نويسنده , , R.، نويسنده ,
Abstract :
HPLC methodology was investigated for the simultaneous determination of cisapride and ranitidine in small volume paediatric plasma samples. Such a simultaneous determination proved difficult due to the small sample volumes, the low concentrations of the drugs and the different log P values of the two compounds. The two drugs and their respective internal standards were separated “on-cartridge” using HLB Solid Phase Extraction cartridges and the samples quantified by individual HPLC methodologies. The technique has been applied successfully to 60 paediatric plasma samples containing both cisapride and ranitidine.
