Title of article
A QSAR study of the antiallergic activities of substituted benzamides and their structures
Author/Authors
Zhou، نويسنده , , Yu-xin and Xu، نويسنده , , Lu and Wu، نويسنده , , Yaping and Liu، نويسنده , , Bai-li، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 1999
Pages
6
From page
95
To page
100
Abstract
Multiple regression analysis (MRA) and comparative molecular field analysis (CoMFA) have been used in studies of the correlation between the antiallergic activities of substituted benzamides and their structures. The results achieved using CoMFA based on 3D factors are much better than those obtained using MRA based on mainly 2D structural information. The CoMFA results reveal that the steric effects are more important than the electrostatic effects for the activities of substituted benzamides.
Keywords
Comparative molecular field analysis , Substituted benzamides , multiple regression analysis , Quantitative structure–activity relationship
Journal title
Chemometrics and Intelligent Laboratory Systems
Serial Year
1999
Journal title
Chemometrics and Intelligent Laboratory Systems
Record number
1460014
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