Title of article :
A rapid LC–MS method for determination of plasma anion profiles of acidotic patients
Author/Authors :
McKinnon، نويسنده , , William and Lord، نويسنده , , Gwyn A. and Forni، نويسنده , , Lui G. and Peron، نويسنده , , Jean-Marie R. and Hilton، نويسنده , , Philip J.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
7
From page :
179
To page :
185
Abstract :
In metabolic acidosis, the concentrations of anions associated with intermediary metabolism are increased and can make a significant contribution to the observed acidosis. Here we describe a method for the rapid determination of the plasma ultrafiltrate profile of these anions using liquid chromatography coupled to electrospray ionisation mass spectrometry (LC/ESI-MS). The ultrafiltrate from patients with acidosis resulting from various causes were examined and the results compared to control values. Using the LC/ESI-MS method described, a unique plasma ultrafiltrate anion profile was obtained for each of the groups studied that provides rapid diagnosis of the type of underlying acidosis.
Keywords :
Liquid chromatography , mass spectrometry , acidosis , Patients , PLASMA , Ultrafiltrate , Krebs cycle , anion gap , Intermediatry metabolism
Journal title :
Journal of Chromatography B
Serial Year :
2006
Journal title :
Journal of Chromatography B
Record number :
1462956
Link To Document :
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