Title of article
Determination of AKF-PD in whole blood of rat by HPLC-UV
Author/Authors
Cao، نويسنده , , Wei and He، نويسنده , , Lingyun and Liu، نويسنده , , Wenfang and Huang، نويسنده , , Zhizhuang and Cheng، نويسنده , , Zeneng and Peng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
257
To page
259
Abstract
An HPLC-UV method was developed and validated for the determination of AKF-PD in whole blood of rat. Phenacetin was chosen as the internal standard, and the separation was achieved on a C18 column with methanol and 0.02 M phosphate buffer (pH 3.2) as mobile phase. The obtained calibration graphs were linear (r = 0.9999, n = 9) in the range of 0.203–52.0 μg ml−1. The low limit of quantitation was 0.203 μg ml−1. This method can be used to study the pharmacokinetics of AKF-PD in rat.
Keywords
AKF-PD , HPLC , Pharmacokinetics
Journal title
Journal of Chromatography B
Serial Year
2006
Journal title
Journal of Chromatography B
Record number
1462981
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