Title of article
QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography
Author/Authors
Wang، نويسنده , , Sumin and Yang، نويسنده , , Gengliang and Zhang، نويسنده , , Hua and Liu، نويسنده , , Haiyan S. Li، نويسنده , , Zhiwei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
329
To page
333
Abstract
The capability of biopartitioning micellar chromatography (BMC) to describe and estimate pharmacological parameters of cardiovascular system drugs has been studied. The retention of cardiovascular system drugs was studied using different pH of Brij-35 as micellar mobile phase in modified C18 stationary phase. Quantitative retention–activity relationships (QRAR) in BMC were investigated for these compounds. An adequate correlation between the retention factors (log k) and the toxicity (LD50) of cardiovascular system drugs was obtained.
Keywords
QRAR model , Cardiovascular system drugs , Biopartitioning micellar chromatography (BMC)
Journal title
Journal of Chromatography B
Serial Year
2007
Journal title
Journal of Chromatography B
Record number
1463870
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