Author/Authors :
Peeters، نويسنده , , Mariska Y.M. and Kuiper، نويسنده , , Hiltjo and Greijdanus، نويسنده , , Ben and van der Naalt، نويسنده , , Joukje and Knibbe، نويسنده , , Catherijne A.J. and Uges، نويسنده , , Donald R.A.، نويسنده ,
Abstract :
A sensitive gas chromatography–mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2 μg/L using a volume of 0.5 mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1%, respectively. The assay covers the linear concentration range of 2–50 μg/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure.
