Title of article
Analysis of mycophenolic acid in dried blood spots using reversed phase high performance liquid chromatography
Author/Authors
Wilhelm، نويسنده , , A.J. and den Burger، نويسنده , , J.C.G. and Chahbouni، نويسنده , , A. De Vos، نويسنده , , R.M. and Sinjewel، نويسنده , , A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
4
From page
3916
To page
3919
Abstract
At our laboratory a reversed phase high performance liquid chromatography assay was developed for analysis of mycophenolic acid in dried blood spot samples. The assay was validated in the range of 0.74–23.4 mg/L and proved to be accurate and precise. The developed sample pretreatment procedure was consistent and has a recovery of 95.2% for mycophenolic acid. Hematocrit showed to have influence on the physics of the blood spots and thus on the concentration of mycophenolic acid, therefore standard and control samples should be made with a standardized hematocrit.
Keywords
Fingerprick , Mycophenolic acid , HEMATOCRIT , Dried blood spots
Journal title
Journal of Chromatography B
Serial Year
2009
Journal title
Journal of Chromatography B
Record number
1467895
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