Author/Authors :
Lessmann، نويسنده , , H. and Uter، نويسنده , , W. and Diepgen، نويسنده , , T.L. and Drexler، نويسنده , , H. and Fartasch، نويسنده , , M. and Greim، نويسنده , , H. and Hartwig، نويسنده , , A. and Kreis، نويسنده , , P. and Lِser، نويسنده , , E. and Merget، نويسنده , , R. and Merk، نويسنده , , H. and Nowak، نويسنده , , D. and Rothe، نويسنده , , A. and Stropp، نويسنده , , G. and Schnuch، نويسنده , , A.، نويسنده ,
Abstract :
A systematic classification of substances (or mixtures of substances) with regard to various toxicological endpoints is a prerequisite for the implementation of occupational safety strategies. As its principal task the “Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area” of the “Deutsche Forschungsgemeinschaft” (DFG-MAK Commission) derives and recommends maximum workplace concentrations and biological tolerance values (MAK and BAT values) based exclusively on scientific arguments. Several endpoints are evaluated separately in detail, e.g. carcinogenicity, risks during pregnancy, germ cell mutagenicity or contribution to systemic toxicity after cutaneous absorption. Skin- and airway sensitization is also considered; the present paper focuses on these two endpoints.
Keywords :
EU legislation , Skin sensitization , Classification , DFG-MAK Commission
