• Title of article

    Oral bioaccessibility testing and read-across hazard assessment of nickel compounds

  • Author/Authors

    Henderson، نويسنده , , Rayetta G. and Cappellini، نويسنده , , Danielle and Seilkop، نويسنده , , Steven K. and Bates، نويسنده , , Hudson K. and Oller، نويسنده , , Adriana R.، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2012
  • Pages
    9
  • From page
    20
  • To page
    28
  • Abstract
    In vitro metal ion bioaccessibility, as a measure of bioavailability, can be used to read-across toxicity information from data-rich, source substances to data-poor, target substances. To meet the data requirements for oral systemic toxicity endpoints under the REACH Regulation in Europe, 12 nickel substances underwent bioaccessibility testing in stomach and intestinal fluids. A read-across paradigm was developed based on the correlation between gastric bioaccessibility and in vivo acute oral toxicity. The oral LD50 values were well predicted by nickel release (R2 = 0.91). Samples releasing <48% available nickel (mg Ni released/mg available Ni × 100) are predicted to have an LD50 > 2000 mg/kg; while samples releasing >76% available nickel are expected to have an LD50 between 300 and 2000 mg/kg. The hazard classifications (European Regulation on Classification, Labelling and Packaging of Chemical Substances and Mixtures) for all oral systemic endpoints were evaluated based on read-across from three source nickel compounds (sulfate, subsulfide, oxide). Samples releasing <48% available nickel were read-across from nickel oxides and subsulfide. Samples releasing >76% Ni were read-across from nickel sulfate. This assessment suggests that nickel chloride and dihydroxide should be less stringently classified and nickel sulfamate should receive a more stringent classification for oral systemic endpoints than currently assigned.
  • Keywords
    Rat , Classification , Bioavailability , bioaccessibility , nickel , Metal , Acute toxicity , Oral , Read-across , REACH
  • Journal title
    Regulatory Toxicology and Pharmacology
  • Serial Year
    2012
  • Journal title
    Regulatory Toxicology and Pharmacology
  • Record number

    1489730