Author/Authors :
Goebel، نويسنده , , Carsten and Aeby، نويسنده , , Pierre and Ade، نويسنده , , Nadège and Alépée، نويسنده , , Nathalie and Aptula، نويسنده , , Aynur and Araki، نويسنده , , Daisuke and Dufour، نويسنده , , Eric and Gilmour، نويسنده , , Nicola and Hibatallah، نويسنده , , Jalila and Keller، نويسنده , , Detlef and Kern، نويسنده , , Petra and Kirst، نويسنده , , Annette and Marrec-Fairley، نويسنده , , Monique and Maxwell، نويسنده , , Gavin and Rowland، نويسنده , , Joanna and Safford، نويسنده , , Bob and Schellauf، نويسنده , , Florian and Schepky، نويسنده , , Andreas and Seaman، نويسنده , , Chris and Teichert، نويسنده , , Thomas and Tessier، نويسنده , , Nicolas and Teissier، نويسنده , , Silvia and Weltzien، نويسنده , , Hans Ulrich and Winkler، نويسنده , , Petra and Scheel، نويسنده , , Julia، نويسنده ,
Abstract :
Characterisation of skin sensitisation potential is a key endpoint for the safety assessment of cosmetic ingredients especially when significant dermal exposure to an ingredient is expected. At present the mouse local lymph node assay (LLNA) remains the ‘gold standard’ test method for this purpose however non-animal test methods are under development that aim to replace the need for new animal test data. COLIPA (the European Cosmetics Association) funds an extensive programme of skin sensitisation research, method development and method evaluation and helped coordinate the early evaluation of the three test methods currently undergoing pre-validation. In May 2010, a COLIPA scientific meeting was held to analyse to what extent skin sensitisation safety assessments for cosmetic ingredients can be made in the absence of animal data. In order to propose guiding principles for the application and further development of non-animal safety assessment strategies it was evaluated how and when non-animal test methods, predictions based on physico-chemical properties (including in silico tools), threshold concepts and weight-of-evidence based hazard characterisation could be used to enable safety decisions. Generation and assessment of potency information from alternative tools which at present is predominantly derived from the LLNA is considered the future key research area.
