Title of article :
Good relationship between saliva cotinine kinetics and plasma cotinine kinetics after smoking one cigarette
Author/Authors :
Yuki، نويسنده , , Dai and Kikuchi، نويسنده , , Akira B. Miura، نويسنده , , Naoki and Kakehi، نويسنده , , Aoi and Onozawa، نويسنده , , Masahiro، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
6
From page :
240
To page :
245
Abstract :
This study investigated the relationship between plasma and saliva cotinine kinetics after smoking one cigarette and the relationship between cotinine kinetics and estimated nicotine intake, which was calculated as mouth level exposure (MLE) of nicotine, from smoking two test cigarettes with different nicotine yields. This study was conducted in 16 healthy adult Japanese smokers, who did not have null nor reduced-activity alleles of CYP2A6, with a quasi-randomized crossover design of smoking a low-tar cigarette or a high-tar cigarette. Saliva cotinine showed similar concentration profiles to plasma cotinine, and all of the calculated pharmacokinetic parameters of cotinine showed the same values in plasma and saliva. The Cmax and AUC of cotinine showed almost the same dose-responsiveness to the estimated MLE of nicotine between plasma and saliva, but the tmax and t1/2 of cotinine were not affected by the estimated MLE of nicotine in either plasma or saliva. The results show that saliva cotinine kinetics reflects plasma cotinine kinetics, and measurement of saliva cotinine concentration gives the same information as plasma cotinine on the nicotine intake. Thus, saliva cotinine would be a good and less-invasive exposure marker of cigarette smoke, reflecting the plasma cotinine concentration and kinetics.
Keywords :
nicotine , Cotinine , Pharmacokinetics , Smoking cigarette , Mouth level exposure , Japanese smokers
Journal title :
Regulatory Toxicology and Pharmacology
Serial Year :
2013
Journal title :
Regulatory Toxicology and Pharmacology
Record number :
1491876
Link To Document :
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