Can Vascular Pathology in Cerebral and Coronary Fields Predict Peripheral Artery Disease in a Cohort of Diabetic Patients?

Background:Diabetes mellitus, a metabolic disorder of absolute or relative insulin deficiency, is characterized by micro and macro-vascular complications. This process of vascular pathology proceeds at a uniform rate throughout the body. Eventually it may be manifested as atherosclerotic changes in cerebral, coronary and peripheral arteries Variables like central adiposity, altered metabolism, elevated blood pressure, proteinuria causes resistance. Methods:A retrospective cross-sectional study was carried out on 4482 diabetic patients attending the “Diabetes Management Center” Services Hospital, Lahore. Known determinates of past vascular disease PVD were assessed. An artery disease index was formulated by the presence or absence of lower limb pulses. Results:Past history of CVA was significantly associated with PVD with a p-value of 0.002. Similarly past history of M1 (p=0.000), hypertension (p=0.000), proteinuria (p=0.000) were all significantly present in patients with PVD. There was lack of association between cigarette smoking (p= 0.463) and PVD. Conclusion:Past history of CVA and MI, Hypertension and Protienuria are all significantly present in Diabetic patients with Peripheral Vascular disease.