Title of article :
Separation of the four pairs of enantiomers of vincamine alkaloids by enantioselective high-performance liquid chromatography
Author/Authors :
Caccamese، نويسنده , , Salvatore and Principato، نويسنده , , Grazia، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
8
From page :
47
To page :
54
Abstract :
The four enantiomeric pairs of vincamine group alkaloids were separated by HPLC using Chiralpak AD as chiral stationary phase (CSP) and various n-hexane–2-propanol and n-hexane–ethanol mobile phases. (+)-cis-Vincamine, which is used in pharmaceutical preparations, is eluted much faster than its optical isomer, with separation factors of 2.4 and 3.5, respectively in these mobile phases. Other CSPs gave negative results. A chiral recognition mechanism is proposed and circular dichroism spectra of the individual enantiomers are presented.
Keywords :
Vincamine alkaloids , Alkaloids
Journal title :
Journal of Chromatography A
Serial Year :
2000
Journal title :
Journal of Chromatography A
Record number :
1502432
Link To Document :
بازگشت