Title of article :
Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils
Author/Authors :
Martins، نويسنده , , Clلudia P.B. and Awan، نويسنده , , M. Ali and Freeman، نويسنده , , Sally and Herraiz، نويسنده , , Tomلs and Alder، نويسنده , , John F. and Brandt، نويسنده , , Simon D.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
6
From page :
115
To page :
120
Abstract :
A number of N,N-dialkylated tryptamines show psychoactive properties in man which resulted in a renewed interest in psychopharmacological research. Attempts to manufacture these derivatives are increasing within a clandestine environment, where literature procedures are adapted and information is exchanged on the Internet. One such example is based on the thermolytic decarboxylation of tryptophan to tryptamine as the precursor to psychoactive derivatives. This procedure was proposed to make use of household solvents such as turpentine substitute and white spirit to facilitate decarboxylation. Discussions on websites also suggested the catalytic use of natural oils in order to accelerate these reactions. In this research, the analytical characterization of this preparation procedure was carried out using gas chromatography–ion trap single and tandem stage mass spectrometry in electron and chemical ionization mode that led to the identification of previously unreported 1-mono and 1,1-disubstituted tetrahydro-β-carboline (THBCs) by-products. The tryptamine product and several THBC by-products were determined quantitatively and a “fingerprint” analysis of the crude products allowed for the differentiation between the essential oil catalysts involved as indicated by the presence of tetrahydro-β-carbolines and their imine intermediates.
Keywords :
Tryptamines , Hallucinogens , forensic , Decarboxylation , GC–MS , Tetrahydro-?-carbolines
Journal title :
Journal of Chromatography A
Serial Year :
2008
Journal title :
Journal of Chromatography A
Record number :
1511353
Link To Document :
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