Title of article :
Implementation of an automated on-line high-performance liquid chromatography monitoring system for ‘cycle to cycle’ control of simulated moving beds
Author/Authors :
Langel، نويسنده , , Christian and Grossmann، نويسنده , , Cristian and Morbidelli، نويسنده , , Massimo and Morari، نويسنده , , Manfred and Mazzotti، نويسنده , , Marco، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
10
From page :
8806
To page :
8815
Abstract :
In continuous chromatography simulated moving bed (SMB) is a firmly established powerful technique for the separation of fine chemicals and enantiomers. The use of a controller could improve the operation conditions and increase the productivity of an SMB unit. However, the performance of any controller is greatly affected by the reliability and the quality of the feedback information from the plant. Therefore, to overcome the limitations of optical detectors, such as UV and polarimeter, an automated on-line HPLC monitoring system was developed and installed to monitor the product streams. The performance of the system is tested experimentally separating a mixture of guaifenesin enantiomers on Chiralcel OD columns with ethanol as mobile phase in our laboratory SMB unit under both linear and nonlinear chromatographic conditions. The results show that the new monitoring system provides precise and accurate data about the concentration of the components in the two product streams. Moreover, they prove that despite disturbances a combination of the controller and the new on-line monitoring system allows to fulfill the product specifications and to improve the performance of the process in terms of feed throughput and solvent consumption.
Keywords :
Simulated moving bed chromatography , Repetitive model predictive control (RMPC) , Chiral chromatography , Automated on-line HPLC monitoring system
Journal title :
Journal of Chromatography A
Serial Year :
2009
Journal title :
Journal of Chromatography A
Record number :
1512617
Link To Document :
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