Modified Equilibrium-Dispersive Model for the interpretation of the efficiency of columns packed with core–shell particle

A modified Equilibrium Dispersive (ED) Model is proposed for the modeling of chromatographic processes in columns packed with shell-particle adsorbents and operated under very high pressures. This new model was validated on the basis of experimental results obtained with 2.1 mm × 150 mm columns packed with superficially porous 1.7 μm Kinetex-C18 particles and with classical columns packed with 1.7 μm BEH-C18 fully porous particles. The influence of the heat friction on the performance of these columns was analyzed by comparing the experimental and calculated peak profiles. Moreover a theoretical analysis of the influence the solid-core conductivity on the column efficiency was discussed.