Author/Authors :
Neue، نويسنده , , Uwe Dieter and Wheat، نويسنده , , Thomas E and Mazzeo، نويسنده , , Jeffrey R and Mazza، نويسنده , , Cecilia B. and Cavanaugh، نويسنده , , Jie-Xiu and Xia، نويسنده , , Fang and Diehl، نويسنده , , Diane M، نويسنده ,
Abstract :
Ionizable compounds experience a drastic difference in preparative loadability as a function of pH. It can be shown that the preparative loadability of a compound in the ionic form is by a factor of 20 or more inferior to the loadability of the same compound in the unionized form. In this paper, we demonstrate the reason for this behavior, and show practical applications of the principle.
