Title of article
Differences in preparative loadability between the charged and uncharged forms of ionizable compounds
Author/Authors
Neue، نويسنده , , Uwe Dieter and Wheat، نويسنده , , Thomas E and Mazzeo، نويسنده , , Jeffrey R and Mazza، نويسنده , , Cecilia B. and Cavanaugh، نويسنده , , Jie-Xiu and Xia، نويسنده , , Fang and Diehl، نويسنده , , Diane M، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
12
From page
123
To page
134
Abstract
Ionizable compounds experience a drastic difference in preparative loadability as a function of pH. It can be shown that the preparative loadability of a compound in the ionic form is by a factor of 20 or more inferior to the loadability of the same compound in the unionized form. In this paper, we demonstrate the reason for this behavior, and show practical applications of the principle.
Keywords
Adsorption isotherms , Ionic compounds , Preparative chromatography
Journal title
Journal of Chromatography A
Serial Year
2004
Journal title
Journal of Chromatography A
Record number
1520303
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