Capillary electrochromatography in the size-exclusion mode

In this review the literature on the application of capillary electrochromatography (CEC) for size-based separations of macromolecules is summarized. Opportunities and limitations of CEC specially related to the size-exclusion mode (SEEC) are indicated. Applications with synthetic polymer samples as well as with biomacromolecules (polysaccharides, proteins) are shown. The prospects for a further development and application of SEEC are discussed.