Alkylsilyl derivatives for gas chromatography

Alkylsilyl reagents are the most widely used reagents for the derivatization of polar compounds containing labile hydrogen atoms for gas chromatography. In this article the reagents and reaction conditions for the formation of trimethylsilyl, alkyldimethylsilyl (particularly t-butyldimethylsilyl), cyclic siliconides, haloalkyldimethylsilyl, and flophemesyl (pentafluorophenyldimethylsilyl) derivatives for a wide range of functional groups are reviewed. The importance of steric hindrance on reaction rates and completion, choice of reaction conditions, stability of derivatives, and options for selective detection are described.