Development of solvent micro-extraction combined with derivatization

Solvent microextraction (SME), such as single-drop microextraction (SDME), hollow-fiber liquid-phase microextraction (HF-LPME) and dispersive liquid–liquid microextraction (DLLME), has been explored for its ability to cover a wide range of analytes. Microextraction, combined microextraction with derivatization can greatly improve separation, detectability and compound identification, expand its scope of application, and improve the effect of analysis. In this view, the article not only highlights the development of the microextraction technology such as SDBE, HF-LPME and DLLME, but also improves the key strategies of microextraction coupled to derivatization in analytical chemistry. In order to encourage further development of microextraction-derivatization, its coupling with different analytical techniques such as GC or GC–MS, HPLC, and the other technique has also been discussed.