Enantioseparation on mono(6A-N-allylamino-6A-deoxy)permethylated β-cyclodextrin covalently bonded silica gel

A chiral selector, mono(6A-N-allylamino-6A-deoxy)permethylated β-cyclodextrin, was synthesized through a facile synthetic route and chemically immobilized onto porous silica gel via hydrosilylation to afford a cyclodextrin based chiral stationary phase MeCD-CSP. This chiral stationary phase exhibited good enantioselectivity under standard HPLC conditions. The optimal resolution of 1-(p-bromophenyl)ethanol and bromopheniramine was achieved under normal-phase conditions using a mobile phase comprising n-hexane (hexane) and 2-propanol (IPA). The enantioseparation of warfarin, suprofen and a series of flavanones under reversed-phase conditions were optimized and efficient enantioseparations for these analytes were obtained.