Comparison between sample disruption methods and solid–liquid extraction (SLE) to extract phenolic compounds from Ficus carica leaves

Sea sand disruption method (SSDM) and matrix solid phase disruption (MSPD) were compared to solid–liquid extraction (SLE) for extraction of phenolic compounds from the Ficus carica leaves. Statistical treatment, ANOVA-single factor, was used to compare the extraction yields obtained by these methods, and for the majority of the extracted compounds, significantly higher yields were obtained by the solid disruption methods. Both solid disruption methods are faster and ecologically friendly, but the sea sand method was more reproducible (RSD < 5% for most compounds), and was also the least expensive method. Recoveries above 85% were obtained for chlorogenic acid, rutin, and psoralen using the sea sand extraction method.