Title of article
Stability-indicating high-performance liquid chromatographic assay and analysis of decomposition products of 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propanoic acid
Author/Authors
Cheung، نويسنده , , Andrew P and Struble، نويسنده , , Elaine and Nguyen، نويسنده , , Namphuong and Liu، نويسنده , , Paul، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
10
From page
179
To page
188
Abstract
A stability-indicating HPLC assay has been developed for 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propanoic acid (XK469). XK-469 is the 7-chloro analog of herbicide Quizalofop and is currently under development as an antineoplastic agent. HPLC separation of XK469 is achieved with an ODS column using isocratic elution of an aqueous MeOH mobile phase. The assay is reproducible (RSD=0.9%), linear (r2=0.999), accurate (error=1.2%) and sensitive (LDL=1.2 ng). The HPLC separates XK469 from its forced decomposition products. Identities of the decomposition products have been elucidated.
Keywords
Chloroquinoxalinyloxyphenoxypropanoic acid , Aryloxyphenoxypropanoic acid
Journal title
Journal of Chromatography A
Serial Year
2000
Journal title
Journal of Chromatography A
Record number
1526812
Link To Document